In a study of 70 undergraduates, researchers tested whether attractiveness and mating strategy (short vs. long term) influence receptivity to pick-up lines. Replicating previous research, women preferred men who took the innocuous “Do you have the time?” route, or those who used direct pick-up lines – e.g., “…I’d like to meet you. What’s your name?” Cute or flippant lines — “Can I get a picture of you so I can show Santa what I want for Christmas?” — continued to strike out. But women preferred attractive men for short-term relationships, regardless of the type of pick-up line he used. For long-term relationships, women preferred men who used direct or innocuous lines. Even though flippant lines made men seem outgoing and humorous, they also made them seem less trustworthy and less intelligent. Men who used direct lines were seen as the most trustworthy and intelligent.
Senko, C., & Fyffe, V. (2010). An evolutionary perspective on effective vs. ineffective pick-up lines. Journal of Social Psychology, 150(6), 648-667. doi:10.1080/00224540903365539